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      Teton™ CytoProfiling

      Single cell and spatial co-detection of RNA, protein, and cell morphology at subcellular resolution with no library prep and next-day results

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      Cellular decoding unlocked

      Every layer of biology – from cell morphology to RNA and protein expression – reveals critical insights into cell function. Teton CytoProfiling enables precise single cell spatial imaging of RNA, proteins, phospho-proteins, and cell morphology across hundreds of thousands to millions of cells with less than 1 hour of sample preparation and next-day results. From performing drug screens to resolving cell lineage trajectories, Teton unlocks single cell spatial multiomic analysis at scale.

      Rich morphology and multiomic readouts

      Morphology
      RNA detection
      Protein detection
      DISS

      Morphology

      • Visualize nucleus, cell membrane, actin, endoplasmic reticulum, Golgi apparatus, and mitochondria
      • Automated, onboard detection by ABC Sequencing™
      • Multiplex feature detection with reversible cell labels
      • Sequential RNA and protein imaging with low background
      • Real-time segmentation and morphology feature extraction with onboard primary analysis

      RNA detection

      • Profile 350 transcripts with subcellular resolution
      • Less than 1 hour off-instrument workflow with automated onboard probe hybridization, amplification, and detection
      • Next-day run times with ABC sequencing of transcript-specific barcodes
      • Enhanced sensitivity and dynamic range with detection of 1000s transcripts/cell
      • Flexible panel options with pre-designed or custom configurations*

      *Coming in 2025

      Protein detection

      • Map 50 cell surface, intracellular, and phospho proteins at subcellular spatial resolution
      • Co-detect protein and RNA in same sample with optimized chemistries
      • Automated onboard antibody binding, amplification, and detection by ABC sequencing
      • Choose from pre-designed panels or custom options* with no conjugation or barcoding required

      Direct In Sample Sequencing (DISS)

      • Unlock targeted and untargeted RNA sequencing at subcellular spatial resolution
      • Up to 100 cycles of sequencing with low phasing or pre-phasing errors
      • High on-target coverage for targeted sequencing applications
      • Enables unbiased 3’ sequencing, in situ CRISPR guide sequencing, expressed mutation detection, and more!

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      How does it work?

      Cell Preparation
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      Sample Preparation (<1 hour)
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      Sequencing + Primary Analysis (1 day)
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      Data Visualization
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      See how Teton Chemistry Enables Multiomic Detection

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      See how Teton Chemistry Enables Multiomic Detection

      Watch Video

      Designed for your science

      Teton panels are available as curated, supported panels containing biologically relevant targets for a specific research area. Each panel is designed for the co-detection of cell typing markers, signaling molecules, and important drivers of cell function in normal and disease states.

      Sample Compatibility

      • Immortalized cell lines
      • Primary cell lines
      • Co-cultures
      • Cell suspensions

      Flexible protein customization

      With Teton, we provide flexible paths to protein customization:

      Custom add-on panels 
      Enables users to profile up to 88 unique primary antibodies coupled with our Teton detection probes. A simple workflow requires no chemical cross-linking and reduces time to generate a fully custom panel from months to hours.

      Teton Focus Panels
      Pre-designed sets of 24 target probes across immunology, oncology, neuroscience, and cell cycle research areas. Users can mix and match up to 3 focus panels per run or combine 2 focus panels with up to 24 custom antibodies.

      View the focus panel target list >

      Available pre-designed panels

      MAPK panels
      Comprehensive critical signaling cascades involved in cell cycle regulation, transcription, DNA replication, stress response, and apoptosis.

      Immuno-oncology panel
      Co-detect immune cell markers, cytokines, signaling molecules, and biologically relevant targets involved in inflammation, innate and adaptive immunity, antiviral defense, and immune checkpoints. 

      View list of targets > 

      Neuroscience Panel
      Markers to study neurodegenerative disorders, like Alzheimer’s and Parkinson’s disease, psychiatric disorders, and neurological cancers. 

      View list of targets > 

      Ordering Information

      Teton Panel & Reagents
      Teton Cartridge and Reagent Kit 860-00039
      Teton Panel Kits  
      Teton Human Neuro Panel Kit 830-00038
      Teton Human Immuno Panel Kit 830-00039
      Teton Human MAPK & Cell Cycle Panel Kit 830-00040
      Teton Human MAPK & Apoptosis Panel Kit 830-00041
      Custom Protein Add-On
      Teton Custom Add-On Protein Panel Assembly Kit 860-00036
      Teton Diversity Spike-In 830-00043
      Teton Optimization Kit
      Teton Cell Paint Probe Kit 830-00045
      Teton Slide Kits
      Teton Slide Kit, PLL – 12 Well (2-pack) 860-00031
      Teton Slide Kit, Uncoated – 12 Well (2-pack) 860-00032
      Teton Slide Kit, PLL – 1 Well (2-pack) 860-00029
      Teton Slide Kit, Uncoated – 1 Well (2-pack) 860-00030
      Teton Flow Cell Assembly Tool Set
      Teton Flow Cell Assembly Tool Set 860-00033
      Teton Flow Cell Assembly Kits
      Teton, Flow Cell Assembly Kit, 1-Well (2-pack) 860-00027
      Teton, Flow Cell Assembly Kit, 12-Well (2-pack) 860-00028

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