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      Teton™ CytoProfiling

      Single cell and spatial co-detection of RNA, protein, and cell morphology at subcellular resolution with no library prep and next-day results

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      Cellular decoding unlocked

      Every layer of biology – from cell morphology to RNA and protein expression – reveals critical insights into cell function. Teton CytoProfiling enables precise single cell spatial imaging of RNA, proteins, phospho-proteins, and cell morphology across hundreds of thousands to millions of cells with less than 1 hour of sample preparation and next-day results. From performing drug screens to resolving cell lineage trajectories, Teton unlocks single cell spatial multiomic analysis at scale.

      Rich morphology and multiomic readouts

      Morphology
      RNA detection
      Protein detection
      DISS

      Morphology

      • Visualize nucleus, cell membrane, actin, endoplasmic reticulum, Golgi apparatus, and mitochondria
      • Automated, onboard detection by ABC Sequencing™
      • Multiplex feature detection with reversible cell labels
      • Sequential RNA and protein imaging with low background
      • Real-time segmentation and morphology feature extraction with onboard primary analysis

      RNA detection

      • Profile 350 transcripts with subcellular resolution
      • Less than 1 hour off-instrument workflow with automated onboard probe hybridization, amplification, and detection
      • Next-day run times with ABC sequencing of transcript-specific barcodes
      • Enhanced sensitivity and dynamic range with detection of 1000s transcripts/cell
      • Flexible panel options with pre-designed or custom configurations*

      *Coming soon

      Protein detection

      • Map 50 cell surface, intracellular, and phospho proteins at subcellular spatial resolution
      • Co-detect protein and RNA in same sample with optimized chemistries
      • Automated onboard antibody binding, amplification, and detection by ABC sequencing
      • Choose from pre-designed panels or custom options* with no conjugation or barcoding required

      Direct In Sample Sequencing (DISS)

      • Unlock targeted and untargeted RNA sequencing at subcellular spatial resolution
      • Up to 100 cycles of sequencing with low phasing or pre-phasing errors
      • High on-target coverage for targeted sequencing applications
      • Enables unbiased 3’ sequencing, in situ CRISPR guide sequencing, expressed mutation detection, and more!

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      How does it work?

      Cell Preparation
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      Sample Preparation (<1 hour)
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      Sequencing + Primary Analysis (1 day)
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      Data Visualization
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      See how Teton Chemistry Enables Multiomic Detection

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      See how Teton Chemistry Enables Multiomic Detection

      Watch Video

      Designed for your science

      Sample types and segmentation models

      Teton CytoProfiling is compatible with diverse sample types from adherent cells to cell suspension to primary cells or cell lines. With advanced segmentation models, you can get high-quality data for cell surface and intracellular markers in cell types ranging from immune to neural cell lines.

       

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      Cell Suspensions      		 Adherent-Cells_2025-09-11-203459_owmi
      Adherent Cells

       

      Pre-designed panels

      Teton panels are available as curated, supported panels containing biologically relevant targets for a specific research area. Each panel is designed for the co-detection of cell typing markers, signaling molecules, and important drivers of cell function in normal and disease states.

       

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      MAPK Cell Cycle

      MAP Kinase Signaling
      Cell cycle regulation
      Transcription
      DNA replication

      View target list →

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      MAPK Apoptosis

      MAP Kinase Signaling
      Pro- and anti-apoptosis
      Transcription
      Stress response

      View target list →

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      Immuno Oncology

      Immunophenotyping
      Immune Response
      Checkpoint Inhibitors
      Hematology Oncology research

      View target list →

      Neuroscience_2025-09-11-203547_caco

      Neuroscience

      Neurodifferentiation
      Neurotransmission & Synaptic function
      Neurodegeneration
      Neuroinflammation

      View target list →

      Optimization reagents

      Cell culture optimization: Test your cell culture conditions before committing to a full AVITI24 run. Simply plate cells, perform cell paint, assemble the flow cell, and visualize on either an AVITI24 or a microscope.

      Antibody screening kit: Screen antibodies for use in a custom antibody panel. Couple your primary antibody of interest to a Teton detection probe, apply to cells, assemble the flow cell and read-out on your AVITI24—in less than 7 hours, you can determine antibody performance in a Teton assay.

       

      Flexible protein customization

      With Teton, we provide flexible paths to protein customization:

      Custom add-on panels: Enables users to profile up to 88 unique primary antibodies coupled with our Teton detection probes. A simple workflow requires no chemical cross-linking and reduces time to generate a fully custom panel from months to hours.

      Teton Focus Panels: Pre-designed sets of 24 target probes across immunology, oncology, neuroscience, and cell cycle research areas. Users can mix and match up to 3 focus panels per run or combine 2 focus panels with up to 24 custom antibodies.

      View target list →

       

       

      Ordering Information

      Teton Panel Kits & Reagents
      Teton Cartridge & Reagent Kit 860-00039
      Teton Human Neuro Panel Kit 830-00038
      Teton Human Immuno Panel Kit 830-00039
      Teton Human MAPK & Cell Cycle Panel Kit 830-00040
      Teton Human MAPK & Apoptosis Panel Kit 830-00041
      Protein Add-Ons
      Teton Custom Add-On Protein Panel Assembly Kit 860-00036
      Teton Focus Protein Panel, Set 1, Cytokine Signaling 830-00046
      Teton Focus Protein Panel, Set 2, T Cell Activation 830-00047
      Teton Focus Protein Panel, Set 3, Innate Immunity 830-00048
      Teton Focus Protein Panel, Set 1, Cell Metabolism 830-00049
      Teton Focus Protein Panel, Set 2, Cell Stress & Apoptosis 830-00050
      Teton Focus Protein Panel, Set 3, Gene Regulation 830-00051
      Teton Focus Protein Panel, Set 1, Neurodegeneration 830-00052
      Teton Focus Protein Panel, Set 2, Neurodevelopment 830-00053
      Teton Focus Protein Panel, Set 3, Neuroinflammation 830-00054
      Teton Diversity Spike-In 830-00043
      Teton Custom Add-On Protein Buffer 830-00044
      Optimization and Screening Kits
      Teton Cell Paint Probe Kit 830-00045
      Teton Onboard Cell Paint Imaging Kit 860-00047
      Teton Custom Antibody Screening Kit 860-00035
      Teton Slide Kits
      Teton Slide Kit, PLL – 48 Well (2-pack) 860-00041
      Teton Slide Kit, Uncoated – 48 Well (2-pack) 860-00042
      Teton Slide Kit, PLL – 12 Well (2-pack) 860-00031
      Teton Slide Kit, Uncoated – 12 Well (2-pack) 860-00032
      Teton Slide Kit, PLL – 1 Well (2-pack) 860-00029
      Teton Slide Kit, Uncoated – 1 Well (2-pack) 860-00030
      Teton Accessories
      Teton Flow Cell Assembly Tool Set 860-00033
      Teton Slide Kit Tool 810-00021
      Teton Slide Kit Tray (2-Pack) 860-00044
      Teton Flow Cell Assembly Kits
      Teton, Flow Cell Assembly Kit, 1-Well or 48 Well (2-pack) 860-00027
      Teton, Flow Cell Assembly Kit, 12-Well (2-pack) 860-00028

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