Integrated multiomics and genomics for cancer research

Multiomics for Cancer Research with Element Biosciences

Reveal the full complexity of cancer biology 

Cancer biology is complex and studying it rarely fits into a single experiment or a single data type. You need to connect genomic alterations to gene expression, protein expression, and functional responses across heterogeneous cell populations. But today, generating those insights often means stitching together multiple platforms and workflows, driving up cost and complexity and making it harder to move as fast as science demands.

In just a single platform, AVITI24™ unifies high-accuracy next-generation sequencing and powerful single cell multiomic capabilities. With flexible throughput, sensitive rare variant detection, and high-throughput functional screening, AVITI24 gives cancer researchers a view of genomic variation, cellular diversity, and molecular mechanisms driving disease, all while reducing hands-on time.

Why choose AVITI24 for cancer research: 

Get a complete view of disease mechanisms: Combine NGS and spatial, single cell multiomics in one platform, reducing the number of systems needed for your discoveries. 

Detect rare variants with confidence: Leverage Q50+ sequencing accuracy with Cloudbreak UltraQ™ for the sensitive detection of low VAF variants, fusions, rare alleles, and minimal residual disease (MRD) research.

Select the right sequencing scale: Choose the throughput and read lengths you need for WGS, comprehensive genomics profiling (CGP), MRD, single cell sequencing, or RNA profiling, with flexibility enabled by fully independent dual flow cells.

Accelerate target discovery: Discover RNA, protein, morphology, spatial context, and dynamic response with next-day results and no library prep. 

Streamlined target capture for CGP, exome sequencing, and MRD: Shorten target capture workflows and reduce hands-on time by moving post-hybridization steps onto the sequencing platform while maintaining high accuracy with Trinity™ sequencing.  

Applications in cancer research

	Solid tumor profiling Confidently detect somatic variants, including SNVs, CNVs, and fusions, in FFPE tumor samples with simplified, high-accuracy Trinity target capture sequencing solutions.
	Low VAF detection Identify low-frequency variants and gene fusions critical for understanding relapse and residual disease with high specificity using Cloudbreak UltraQ™ sequencing kits with Q50+ quality.
	Checkpoint inhibitor evaluation Assess T cell activation, exhaustion, and checkpoint protein expression at single cell and sub-cellular resolution to understand mechanisms of response and resistance in immuno-oncology research.
	Drug screening Leverage combined multiomic and morphology readouts to identify mechanisms of action, off-target effects, and responder subpopulations in cancer cells.
	Optical pooled screening Easily perform high-throughput optical pooled screening, linking CRISPR perturbations to transcriptomic, proteomic, and morphological phenotypes with Teton Atlas and direct gRNA sequencing.