Panos™ Spatial Profiling
The power of sequencing—directly in tissue.
Panos is the upcoming spatial profiling solution on AVITI24™ for fresh frozen and FFPE tissues. Identify cells types, investigate pathway activity, and map expressed cancer variants within the tumor microenvironment, all in the same tissue section.
Map genotype to phenotype in spatial context
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Understanding tumor biology requires connecting genetic variation, gene expression, cellular phenotypes, and the tumor microenvironment. Traditional assays often capture these layers separately. Panos brings them together in one tissue section. Sequence genetic variants directly in tissue Direct in situ sequencing of expressed SNPs, indels, and fusions in the tissue section.
Map tumor variants within the microenvironment Locate genetically distinct tumor clones and investigate their relationships with immune cells, stroma, and the tissue microenvironment.
Investigate how tumors evolve, progress, and resist therapy Localize populations carrying resistance-associated variants and explore the pathways and cellular neighborhoods associated with their persistance. |
Start with curated panels, or design your own
Curated content
Tissue-specific panels of roughly 500 genes for cell typing and pathway analysis, paired with pan-cancer variant panels covering 100 hotspot amplicons and 30 gene fusions.
Custom in weeks, not months
Define, review and order a custom panel in weeks. Add up to 500 custom gene targets or design a fully custom panel of up to 1,000 genes.
Add protein for high resolution cell phenotyping
Immune-focused protein profiling, with expanded plexity and custom targets planned.