AVITI Dx™ System

    A mid-throughput benchtop sequencer, CE-marked as a Class A IVD under the EU IVDR, with dual boot mode: IVD mode for diagnostic sequencing workflows and RUO mode for assay development and clinical research.

    AVITI Dx products are not available for sale in the U.S. and are available only in select countries, as confirmed by Element.

    Built for the demands of a regulated laboratory

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    Precise, high-quality data

    AVITI Dx generates raw DNA sequencing data from a variety of biological samples, with >90% of bases at Q30 or above.

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    Flexibility

    With dual flow cells and individually addressable lanes, run different samples or panels side-by-side without dedicating a full run to a single protocol.

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    Cost-efficient sequencing

    AVITI Dx brings the efficiencies of Avidite Base Chemistry™ (ABC™) to the diagnostic laboratory, helping you manage the cost of sequencing as testing needs grow.

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    A commitment to molecular diagnostics

    AVITI Dx, together with our ISO 13485 quality management system certification, reflects our commitment to providing sequencing technologies for molecular diagnostic laboratories.

    One instrument, two operating modes

    AVITI Dx supports switching between RUO and IVD operating environments, maximizing utilization across research and clinical workflows.

     

    IVD mode

    RUO mode

    Purpose

    Sequencing data generation within
    molecular diagnostic workflows

    NGS assay design and
    clinical research applications

    Workflow

    Locked-down workflows

    Flexible, for development work

    Compatible kits

    Dx sequencing kits only

    RUO sequencing kits only

    Powered by ABC sequencing

    AVITI Dx is powered by Avidite Base Chemistry (ABC), which reduces run costs and improves sequencing performance.

    Linear library molecules are loaded and circularized on-instrument. Rolling circle amplification generates tightly bound polonies for PCR-free amplification that reduces index hopping and other PCR-induced errors. The polonies are sequenced using fluorescent Avidites™ that bind to the polonies creating a prominent signal for highly-accurate base calling and reduced reagent consumption.

    ABC Sequencing from Element Biosciences

    Powered by ABC sequencing

    Intended use

    The AVITI Dx product family delivers precise, high-quality raw DNA sequencing data from a variety of biological samples. The product is intended solely as a data generation tool and does not provide diagnostic interpretations or direct clinical recommendations.

    Consumables and sequencing specifications

    Dx sequencing kits

    Three Dx sequencing kit configurations are available for AVITI Dx. Dx sequencing kits run in IVD mode only.

    Sequencing specifications in IVD mode1

    Kit

    Read length

    Read count¹

    Run time

    Q30

    2x150 CB Freestyle Dx™ High Output

    2x150

    ≥1.2 B

    ≤40 hours

    ≥90%

    2x75 CB Freestyle Dx High Output

    2x75

    ≥1.2 B

    ≤26 hours

    ≥90%

    2x150 CB Freestyle Dx Low Output

    2x150

    ≥300 M

    ≤40 hours

    ≥90%

    1Performance metrics are based on sequencing Element libraries. Actual results may differ due to library type and preparation methods.

    RUO sequencing kits

    For assay development and clinical research in RUO mode, use our Cloudbreak Freestyle™ RUO sequencing kits. RUO sequencing kits can only be used in RUO mode. For sequencing specs in RUO mode, please reference the AVITI24™ sequencing specs in the Cloudbreak™ Sequencing Kits product note.

    System specifications

    Instrument configuration

    Dual flow cells

    In RUO mode: AVITI™ Operating Software
    In IVD mode: AVITI Dx Operating Software

    Ubuntu Core 20.04 LTS operating system

    Operating environment

    Temperature: 18°C to 26°C

    Elevation: <2000 m

    Sound level: ≤62 dB at 3.3 ft

    Dimensions (H x W x D)

    29.5 in x 37.6 in x 28.5 in

    Weight: 155.1 kg / 342 lb

    Power requirements

    100–240 VAC at 50/60 Hz, 15 A

    550 W (average)

    Ordering Information

    AVITI Dx System

    880-00008

    2x150 CB Freestyle Dx High Output

    860-00052

    2x150 CB Freestyle Dx Low Output

    860-00053

    2x75 CB Freestyle Dx High Output

    860-00054

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