We Empower Scientists

Applications of the Element AVITI™ System, our benchtop next-generation DNA sequencer — includes app notes from partners on whole genome, single cell RNA, and targeted sequencing.


Whole Genome Sequencing

Whole genome sequencing (WGS) is the process of determining the entire DNA sequence of an organism’s genome at a specific point in time. An entire genome is defined by chromosomal DNA as well as the DNA in an organism’s cellular organelles such as its mitochondrial DNA. And in plants, the entire DNA sequence of the organism would also include the DNA sequence in its chloroplasts.

WGS provides the highest resolution of all the sequencing approaches due to its comprehensiveness. Therefore, WGS enables the identification of all types of sequence variations. From very small or single nucleotide variations between genomes to variants found in non-coding sequence regions that would be otherwise be missed by more targeted sequencing methods, such as only sequencing the organism’s exome DNA.


RNA Sequencing

RNA sequencing (RNA-Seq) is the process of determining the quantity and the nucleotide sequences of individual RNA sequences in a transcriptome. The transcriptome includes all transcribed RNA including but not limited to mRNA, rRNA, 
and tRNA within a given sample prepared for sequencing at a specific condition and point in time.

RNA-Seq also allows us to understand gene expression levels at the single-cell level, individual cells in multi-cellular contexts, and host-pathogen interactions, amongst many others.


Targeted Sequencing

Targeted sequencing is a rapid and cost-effective way to detect known and novel variants in selected sets of genes or genomic regions because the approach entails sequencing only part of a whole genome or regions of interest without sequencing the entire genome of a sample.

This is accomplished through a pre-sequencing DNA preparation step called Target Enrichment where target DNA sequences are either directly amplified (amplicon or multiplex PCR-based) or captured (hybrid capture-based) and then subsequently sequenced.

Long-Read Sequencing

Element LoopSeq™ 16S

Fungal read lengths with text PNG

Mycobiome Metagenomics with Element LoopSeq™

LoopSeq’s longer read-length directly translates into more accurate taxonomic assignment.
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16S Loop Long-reads vs Sanger Sequencing For Bacterial Isolate Identification

Element LoopSeq™ 16S vs Sanger Sequencing for Bacterial Isolate Identification

If your lab, like many other microbiology labs, has a backlog of isolates sitting at -80°C waiting to be analyzed because the funds and/or time for 16S Sanger sequencing is unavailable, you may be able to clear up space with the Element LoopSeq 16S long-read sequencing.
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Loop Seq metastatic Cancer1

Discover Element LoopSeq™ Long-Reads' Power in Transcriptomics

Dr. Luo used Loop's long-read technology to examine the transcriptome in matched sets of tumor tissue, neighboring normal tissue, and metastatic tissue from lymph nodes.
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16S/18S versus shotgun metagenomics: LoopSeq changes how you choose

Element LoopSeq™ 16S vs Shotgun Metagenomics

Highly accurate Element LoopSeq synthetic long-read sequencing technology changes the approach to shotgun metagenomics approaches, increasing the depth of information researchers can uncover.
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Enabling reproducible microbiome results.

Enabling Reproducible Microbiome Results with Element LoopSeq™

The Element LoopSeq sample prep kit generates robust and reliable data on relative species abundance for microbial metagenomics studies by utilizing single-molecule barcoding and de novo sequence assembly.
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Abstract Green Leaves

Helping Whole Biome Advance Microbiome Research

See what Whole Biome’s founder and CEO, Dr. Colleen Cutcliffe, has to say about Element LoopSeq: “LoopSeq and Whole Biome see a world in which the next step is going to be wanting more comprehensive information. And there are no other sample prep / analytic products out there today that give you better data quality than LoopSeq.”
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Quantification without bias.

Quantification Without Bias - Element LoopSeq™

NGS that relies exclusively on short-read length may not provide reliable, reproducible measurements of relative species abundance. To address this, our team has developed the Element LoopSeq™ sample prep kit, delivering a precise quantitation of relative microbial abundance in a complex sample.
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Jellyfish moving through water

How GC Bias Can Skew Species Quantification and How to Help Stop It

Comparison of the ten most abundant microbes in the sample show close agreement of measured abundance to expected. In addition, we see no GC bias, as shown in the close agreement of measured versus expected across species with different levels of GC content.
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16S Loop Long-reads vs Sanger Sequencing For Bacterial Isolate Identification

Full-Length 16S Microbiome Classification with Element LoopSeq™

The Element LoopSeq kit uses synthetic long-read sequencing, utilizing barcode technology to computationally sequence a single molecule assembled from a cluster of short reads. This enables comprehensive phylogenetic classification all while having a lower error rate and coverage of all nine variable regions.
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Jim Tananbaum Testimonial

"I believe Element will be enabling a major shift in sequencing — moving from research to development and delivery at a much larger scale, because it will be available with very high quality at a very low cost."

Jim Tananbaum Founder & CEO, Foresite Capital
Yaron Hakak Testimonial
"I believe [with AVITI™] we will finally break the technical barriers limiting genomic studies so that scientists anywhere can focus on discovery and see the information they really want."
Yaron Hakak CEO, Jumpcode Genomics
Bryan Roberts Testimonial

"[Element] has been working... to revolutionize DNA sequencing as we know it, creating a decentralized, benchtop, high-performance, high-accuracy tool to power the next decade of biological research and genomics."

Bryan Roberts Partner, Venrock
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Have It All With AVITI™

The Element AVITI™ System reinvents surface chemistry, base detection, and data analysis to offer a flexible and cost-effective platform for a variety of next-generation sequencing applications.