Poster: Spatially resolved variant calling using DISS in cancer tissue

See how Direct In Sample Sequencing (DISS) on AVITI24™ links genotype and phenotype at high resolution—mapping driver mutations and cell types directly in intact tumor tissue, without library prep.

What you’ll learn:

• How DISS chemistry detects somatic mutations, including SNPs, indels, and gene fusions, with in FFPE and fresh frozen cancer tissue.

• How spatial mapping reveals regional clonal architecture and mutational heterogeneity directly on tissue morphology.
• Why long, single-ended probe reads outperform dual-sided or padlock-based methods for sensitive variant detection across diverse expression levels.