Direct in sample RNA sequencing measures gene expression directly within cells and tissues, preserving spatial and morphological context. Using two complementary probe-based strategies, we enable high-resolution, multimodal analysis across optical pooled screens and spatial transcriptomics. Learn how DISS:
- Combines cell morphology, transcriptomics, and protein profiling in a single experiment
- Supports both 3′ transcriptome and targeted RNA feature detection
- Enables direct, library-free quantification and detection of splicing or RNA variants