Poster: Applications of Direct In Sample Sequencing in Optical Pooled Screens and Spatial Transcriptomics

Direct in sample RNA sequencing measures gene expression directly within cells and tissues, preserving spatial and morphological context. Using two complementary probe-based strategies, we enable high-resolution, multimodal analysis across optical pooled screens and spatial transcriptomics. Learn how DISS:

• Combines cell morphology, transcriptomics, and protein profiling in a single experiment
• Supports both 3′ transcriptome and targeted RNA feature detection
• Enables direct, library-free quantification and detection of splicing or RNA variants