Application Note: Rapid, low-input CGP across tissue and liquid biopsy for oncology research

See how Garvan Institute researchers took liquid biopsy and tissue samples from extraction to results in under 48 hours with Trinity Freestyle™.

Early detection, genomic profiling, and MRD research look for different signals in cfDNA—SNVs, CNVs, fusions, and fragmentation patterns. That often means separate prep, capture, and analysis for each. Researchers at the Garvan Institute asked whether one workflow could do it all. They paired the Twist Oncology DNA CGP Panel with Trinity Freestyle sequencing on the AVITI24™ system with a workflow under 48 hours.

Download the application note to see what they found.

What you’ll learn

• How the workflow performed with low-input cfDNA and low-frequency variants
• Which mutational signatures the data supported, and how cfDNA findings compared with matched tissue
• What a unified approach could mean for turnaround time and cost per sample