Direct in sample sequencing (DISS) streamlines your workflow—no library prep, no splitting samples, no integrating disparate datasets, no compatibility issues. For the first time, you can gain high-resolution insights from the native cellular context without compromise.
DISS preserves the spatial and molecular context and integrates with multiomic readouts, all while reducing hands-on time and downstream complexity. Whether you're mapping cellular heterogeneity, performing large-scale pooled screens, or tracking dynamic changes, you get clearer answers, faster.
Direct sample to insight
Whether you’re working with human or non-human species, primary cells, or cell lines, DISS on the AVITI24 brings unmatched flexibility with fully automated load-and-go customization.
Teton Atlas will be available in two outputs, with low output kits now available for pre-order:
Teton Atlas | Teton Atlas | |
Cell Paint | 3-plex | 6-plex |
RNA counting | - | 3' WT or up to 500 Genes |
RNA sequencing | Up to 100bp | Up to 100bp |
Protein | Up to 88-plex | Up to 88-plex |
High output: Ideal for large-scale discovery experiments. Uses poly-A based chemistry that is sequenced via sequential batches to overcome optical crowding for universal and species-agnostic detection.
Low output: Ideal for hypothesis-driven panels, like barcode sequencing or CRISPR screening applications. Full custom workflow design and modular cartridges enable rapid customization.
Both kits are library-prep free and compatible with Teton™ detection chemistries for cell paint and protein detection for multiomic readouts with no batch effects.
Unlock new applications
DISS expands the boundaries of what’s possible, incorporating multiomic readouts and empowering faster, simpler workflows.
- Unbiased cell typing with whole transcriptome coverage.
- TCR/BCR clonotype analysis with 100+ bp of targeted RNA sequencing and assembly of the CDR3 region.
- CRISPR screening, expand the power of optical pooled screens, scaled to thousands of guides
- Mutation detection within intact cells
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The first fully customizable multiomics system
Say goodbye to locked-in workflows and time-consuming, tedious paths to customization. With AVITI24’s programmable platform, cloud-based workflow designer, and a modular sequencing cartridge, you can:
- Build custom workflows through intuitive software with flexible cycle lengths and tunable sensitivity
- Combine multiomic readouts—including cell paint, DISS, and custom protein detection
- Rapidly customize RNA sequencing with our custom designer for ready-to-order probes
- Automatically execute complex protocols, end to end
Uncompromised sequencing quality, directly in cells
High-dimensional insights and customizable workflows demand high-quality data. DISS delivers data you can trust so you ask better questions, make smarter discoveries, and move faster than ever before.
- Batched detection of sequential sequencing overcomes optical crowding, provides tunable sensitivity, and offers flexibility for custom multiomics workflows.
- DISS provides Q30+ sequencing quality through 100+ cycles directly in cells and shows high correlation with single cell RNA-seq methods.
- Overcomes off-target binding possible with probe-based methods
