The 2025 ASHG meeting brought together the human genetics community for five exciting days of ideas, connection, and discovery.
In the opening session, ASHG President, Sarah Tishkoff, PhD, spoke about the resilience of the scientific community amid funding challenges and uncertainty. She emphasized how collaboration, advocacy, and diversity are essential to sustaining discovery. Her message set the tone for the conference and served as a reminder that science moves forward when we do it together.
Later, Francis Collins, MD, PhD, received ASHG’s Lifetime Achievement Award and reminded us why this work matters:
“Let us be people of action and great science, and that will give hope to a hurting world.”
That message of perseverance and optimism carried through the rest of the week—and it was one we felt as we connected with so many passionate scientists.
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Advancing discovery through innovation
One of our highlights this year was hosting Rebecca Barnard, PhD (Twist Bioscience) for a CoLab presentation. She shared a new PCR-free hybrid capture method using Trinity Freestyle™ for detecting pathogenic repeat expansions, like HTT, FMR1, and DMPK, without the amplification bias that can limit accuracy. The presentation sparked some great discussions about new methods to streamline and expand targeted sequencing for more researchers.
Throughout the week, our R&D team and customers shared posters that highlighted the breadth of what’s possible with the AVITI™ family—from studying neurodevelopment to understanding environmental impacts on health.
- Spatial multiomics in neurodevelopment: Integrated transcriptomic, proteomic, and cell morphology data revealed molecular consequences of structural variants in neural development.
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- Direct In Sample Sequencing (DISS) for CRISPR screening: Preserve spatial context, streamline workflows, and add multiomic readouts to optical pooled screening and spatial transcriptomics.
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- PCR-free hybrid capture with Trinity Freestyle: Introduced a bias-free way to detect pathogenic repeat expansions with targeted sequencing using a simplified workflow.
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- Spatially resolved multiomics: A first look at combined RNA and protein mapping across FFPE and fresh frozen tissues on AVITI24™ to expand spatial biology applications.
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- Environmental genomics: Linked environmental exposures to somatic mutation patterns in companion animals, offering new insights into human health.
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Conversations that spark ideas
More than anything, it was the people who made ASHG 2025 memorable. We heard from researchers eager to share results, ask tough questions, and dream about what’s next.
We’re heading home from ASHG feeling reenergized by the creativity, collaboration, and curiosity that define this community. Through partnerships, we’re continuing to build the infrastructure for open innovation and make powerful sequencing technology available to more scientists worldwide.
To everyone who stopped by our booth, joined our sessions, or shared their stories—thank you. We’re excited to keep the momentum going and see where the next year of discovery takes us.