Poster: Spatial Multi-Omics Reveals Mutation Class–Specific Neurodevelopmental Perturbations in 8p Syndrome

Chromosome 8p structural variants drive diverse neurodevelopmental phenotypes, yet their molecular effects remain unclear. Using AVITI24™ to integrate spatial transcriptomic, proteomic, and morphological profiling in iPSC-derived neuronal models, revealed mutation-specific disruptions to neural development.

• 8p deletions reduced expression of genes involved in synaptic and neuronal differentiation
• Inversion duplications disrupted RNA–protein spatial organization
• Morphological profiling revealed distinct phenotypes across mutation classes