Last year we introduced AVITI24, the first integrated platform for in situ multiomics and next generation sequencing. In 2025, we’re taking it even further with new capabilities, added compatibilities, and expanded flexibility.
We’re pushing the boundaries of what’s possible in spatial biology to unlock unprecedented multiomic insights—all in a single run, with no library prep, and ultra-fast results. While AVITI24 already offers robust capabilities, this year’s innovations elevate the platform to a new level of flexibility, scale, and scientific power.
Here’s what’s coming:
New Teton panels: deep phenotyping for immuno-oncology & neuroscience
For expanded use in neuroscience and immuno-oncology research, we introduced new pre-designed Teton™ panels. Each panel is designed to simultaneously analyze cell typing markers, cell signaling molecules, and disease-relevant drivers of cell function. With automated, onboard detection of 350 RNA transcripts, 50 proteins (including phospho-proteins), and 6 cell morphology markers, Teton fixed panels provide the reagents to advance your understanding of these important research areas.
Expanded sample compatibility: suspension cells & beyond
Alongside the new fixed Teton panels, we’ve expanded sample compatibility to include cell suspensions, including T cells, B cells, and PBMCs.
With these optimized protocols and improved segmentation models, you can process hundreds of thousands to millions of cells in a single run, without compromising data quality from intracellular and surface markers. Our enhanced segmentation models even detect fine neuronal structures—like dendrites—that traditional models may miss.
Flexible protein customization
While fixed panels provide protein detection for 50 biologically relevant targets, we understand that you may need to study additional proteins for your research question. For this, we’re providing two paths to protein customization:
- 88-plex add-on panel
Easily couple your own primary antibodies to Teton detection probes—without complex conjugation. Setup takes under two hours, and you can integrate custom probes directly into your fixed panel workflow for up to 138 protein targets in a single run. - 24-plex mini panels
For mix and match customization, we’re also providing pre-designed Teton mini panels containing 24 targets. Use our custom workflow designer and use up to 3 mini panels for the fastest route to protein customization.
Optimization kits: smarter starts, better data
To help you get it right the first time, we’re introducing a new optimization kit with our antibody screening kit so you can validate antibody performance before starting your run.
Simply couple your antibody to Teton detection probes, add to cells, assemble into a Teton flow cell and image on your AVITI24.
48-well consumable: scalable, high-throughput analysis
For added use in drug discovery applications, our 48-well consumable supports high-throughput profiling of dozens of conditions—up to 96 samples in a dual sided run.
In one example, we profiled multiple cell lines across four treatments and ten time points. The result: detailed profiling of cell-type and state-specific responses—all in under a day.
Direct in sample sequencing: library-free, whole transcriptome + targeted RNA sequencing
On AVITI24, we’re excited to unveil a new era in in situ sequencing with direct in sample sequencing (DISS)—no library prep required. Compatible with any species and any sample, we’ll offer fully automated RNA sequencing with reads up to 100 bp.
This groundbreaking tech includes:
- 3′ Whole transcriptome sequencing
- Targeted RNA sequencing for hypothesis-driven panels
- Compatible with simultaneous visualization of cell morphology and protein detection
First, we’ll enable targeted RNA sequencing for CRISPR guide or barcode sequencing and follow with the addition of whole transcriptome sequencing—all within a modular, customizable workflow.
Rapid multiomics customization
It’s not just about getting more data—it’s about getting the right data, faster and with more insight than ever before. With a fully modular cartridge and advanced software tools to design your experiment including a probe designer, you’ll have maximum flexibility to rapidly build fully customizable workflows with the read-outs and cycle length you need for your experiment. No need for time consuming custom solutions or white glove services, just flexible multiomics with a streamlined workflow.
Ready for your next breakthrough?
Whether you're decoding neurodegenerative disease, performing high-throughput CRISPR screens, or exploring novel immune states, continued innovations on AVITI24 give you the flexibility, scale, and depth to uncover what others miss.
The platform is evolving. Your science can too.