The world of multiomics is evolving. Traditional methods require multiple platforms, numerous samples, and extensive data integration to achieve a comprehensive view of biological processes. But what if there were a way to capture deep, multi-dimensional insights in a single experiment—without the need for complex workflows?
Enter AVITI24™, a breakthrough platform that enables high-dimensional co-detection of RNA, morphology, protein, and their dynamic response with spatial resolution. This platform is designed for discovery, empowering researchers to explore biology at unprecedented depths.
Download our infographic to learn more about 5 dimensional multiomics with AVITI24.
Unraveling the 5 dimensions of multiomics
1. RNA Profiling
Gene expression analysis is central to multiomic research, and AVITI24™ enhances sensitivity and dynamic range. With automated onboard probe hybridization and amplification, the platform enables researchers to:
- Profile 350 transcripts with high sensitivity
- Detect thousands of transcripts per cell
This high-throughput capability accelerates transcriptomic research without the need for library prep or extensive sample preparation.
2. Protein Detection
Protein expression and phosphorylation play a central role in cellular function and signaling pathways. AVITI24 delivers unparalleled protein analysis by mapping:
- Up to 138 cell surface, intracellular, and phospho proteins
- Subcellular resolution using automated onboard antibody binding, amplification, and ABC sequencing
By providing this level of detail, AVITI24 helps researchers uncover complex protein interactions and regulatory mechanisms.
3. Morphology Analysis
Cellular structure plays a crucial role in function, development, and differentiation. With AVITI24, researchers can visualize 6 morphological features:
- Nuclei, cell membrane, actin, endoplasmic reticulum, Golgi apparatus, and mitochondria
- Multiplexed feature detection using reversible cell labels
- Real-time segmentation and automated feature extraction
This integrated approach enables a more holistic understanding of cellular morphology alongside molecular insights, shedding light into the relationships between these readouts.
4. Dynamic response
Understanding how cells respond to signals, their environment, or compounds is critical in drug discovery, disease research, and functional genomics. In a single run on the AVITI24, you can:
- Screen cellular responses over time
- Analyze different compounds and dosages
- Profile gene perturbations
With its scalable throughput, researchers can work with 1-well, 12-well, or 48-well formats (coming in 2025), allowing up to 96 samples to be profiled in less than 24 hours with a dual sided run.
5. Spatial Resolution
Knowing where biological molecules are within cells is just as important as knowing what they are. AVITI24 provides single-cell precision, spatially capturing analytes to reveal:
- Intracellular locations of RNA and protein expression
- The intricate organization of cellular structures
This spatial mapping capability enables a new level of insight into how biological components interact within their native environments.
The Future of Multiomics is Here
With AVITI24, we’re redefining what’s possible in multiomic research. By eliminating library preparation and integrating high-dimensional RNA, protein, morphology, and spatial data, researchers can now obtain a comprehensive, multiomic view of biology in a single experiment.
Are you ready to explore biology at unprecedented depths? Learn more about AVITI24.