Poster: Unraveling the mechanism of action for research of cancer therapies using AVITI24

For decades, cancer therapy research has been deciphered by the isolated analyses of transcriptomics, proteomics, or cell morphology to resolve heterogeneous responses in a series of assays requiring multiple biological samples which limit the ability to capture the full picture of the biological response. Integrating these readouts through multiplexed analysis enables a comprehensive understanding of how gene expression relates to functional outcomes and phenotypic effects, offering a holistic view for research of cellular processes impacted by treatment.

Tyrosine kinase inhibitors (TKIs) have significantly advanced the treatment of non-small cell lung cancer (NSCLC) yet achieving consistent and durable patient responses remains a challenge. Here, we utilized AVITI24™, a platform that enables spatial co-detection of RNA, protein, phospho-proteins, and cell morphology at subcellular resolution within a single biological sample to resolve complex systemic responses to TKIs. By consolidating multiomic data in a single assay, this platform facilitates the resolution of multidimensional mechanisms underlying tumor responsiveness and drug resistance. By bridging molecular and morphology insights, our study provides a powerful framework for studying the intricate dynamics of targeted therapies in NSCLC, paving the way for innovative strategies to enhance cancer treatment and personalize patient care.

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