Cell-Free DNA Dynamics of Human Spaceflight - Chris Mason, PhD

Christopher Mason, PhD - Professor, Weill Cornell Medicine

  • Seeking a platform with best-in-class accuracy to analyze samples before and after spaceflight.
  • Inspiration4 visited space for 3.5 days and returned safely with abundant precious samples.
  • Mapping cfDNA helps us understand what happens to the body so we can mitigate risks.
  • Element data quality is on par with competitor data quality, and in some cases better, e.g.
    • >Q30 all the way out to 150 nucleotides, data suggests it could extend much further
    • High mapping rate – very good, well above 99%, key to mapping what cell type affected
  • Plan to utilize AVITI to support sample analysis for other upcoming space missions

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