Cell-Free DNA Dynamics of Human Spaceflight - Chris Mason, PhD

Christopher Mason, PhD - Professor, Weill Cornell Medicine

• Seeking a platform with best-in-class accuracy to analyze samples before and after spaceflight.
• Inspiration4 visited space for 3.5 days and returned safely with abundant precious samples.
• Mapping cfDNA helps us understand what happens to the body so we can mitigate risks.
• Element data quality is on par with competitor data quality, and in some cases better, e.g.
  • >Q30 all the way out to 150 nucleotides, data suggests it could extend much further
  • High mapping rate – very good, well above 99%, key to mapping what cell type affected
• Plan to utilize AVITI to support sample analysis for other upcoming space missions