Complex biological experiments depend on chemistry that can do more—without demanding more. That’s what Teton™ and Teton Atlas™ deliver: onboard detection chemistries designed to deliver flexible, multimodal readouts across RNA, protein, and cell morphology.
Our latest infographic breaks down this chemistry step-by-step. It’s a visual map of how detection happens at scale, using integrated chemistry that puts flexibility and discovery first.
One platform, multiple modalities
The magic of the detection chemistry starts with its modular design. Barcoded oligo probes and antibody conjugates target RNA and proteins, while a range of dyes and reversible cell paints capture the full cellular landscape. With Teton Atlas for Direct In Sample Sequencing (DISS), you can perform true RNA sequencing in its native context.
Want targeted RNA data? Whole transcriptome coverage? Protein detection? Structural context? You don’t have to choose. Teton Atlas is designed to let you combine them and adjust the panel as your study evolves.
No hand-offs. No extra systems.
Traditional spatial and multiomic workflows often rely on a patchwork of imaging, sequencing, and sample prep systems. With Teton Atlas, it’s all onboard. Every step from probe binding to the final sequencing readout happens on a single platform. That means less hands-on time, fewer potential failure points, and seamless progression from detection to readout.
Visualizing the workflows
The infographic walks through the key detection schemes:
- Reversible cell paint: visualization of key morphology features (cell membrane, mitochondria, ER, Golgi, nucleus, and actin) relies on a combination of sequencing readouts and fluorescent stains for improved scalability and increased number of targets.
- Barcoding: Automated, onboard protein and RNA detection with our Teton panels using probes that are sequenced over multiple batches for improved scalability.
- DISS: Exclusively available with Teton Atlas, DISS enables 3' whole transcriptome and targeted RNA sequencing directly in their cellular context.
Each step is engineered for throughput, fidelity, and adaptability—so your experiments can grow without growing more complicated.
See it for yourself
Whether you're studying tissue architecture, immune environments, or disease progression, the ability to get RNA, protein, and morphological context from a single sample opens doors to more meaningful insights. It’s chemistry that matches your biological complexity with technological elegance.
This infographic reveals how we designed a chemistry engine built to scale with your science. Get the visual breakdown of the onboard, multiplexed detection powering 5D multiomics.