Senior/ Assay Scientist, Biochemistry

San Diego, CA R&D - Protein Engineering/Biochemistry Full Time
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Element Biosciences is a multi-disciplinary startup focused on innovating genetic analysis tools for the research and clinical markets. The Company's technology will broaden the end user experience through improved data quality and simplified workflows to benefit discoveries and diagnosis in healthcare. A Scientist contributor opportunity is available for an exciting well-funded and long-term multi-venture backed Life Sciences and IVD start-up company.  Ideal candidates will work with cross-functional departments to understand enzyme requirements and build assays and characterization tools to determine if enzymes meet specifications. Candidates are expected to have the technical expertise and drive to work independently and in combination with a small team to deliver understanding and mitigations to enzyme performance and stability.  Characterization methods will employ both solution-based and surface interaction-based studies. The Scientist will develop advanced methods/techniques for testing and evaluation. The candidate will also be expected to provide project leadership, technical consultation, work direction, and training to junior personnel. The Scientist will work without appreciable direction on assigned projects/programs and participate in determining objectives of assignments.

Duties & Responsibilities

  • Design and execute experiments to characterize the kinetic properties of polymerases and DNA modifying enzymes
  • Independently develop methods to characterize stability and biochemical behaviors of enzymes used in NGS based applications
  • Design novel high-throughput assays to identify candidate enzymes with desired functionalities
  • Develop quality control methods and documentation practices to qualify enzymes for commercial release
  • Collaborate with other teams and cross-function departments to support enzymology needs prior to and through commercialization of technology
  • Present research summaries and develop research plans

Requirements

  • Doctoral (Ph.D.) in biochemistry, molecular biology, bioengineering or a related discipline
  • 1+ years industry related experience and/or training

Relevant Skills

  • Capability to independently develop and qualify assays for characterizing polymerase activity, DNA-binding, interactions with nucleotides
  • Experience with bioanalytical and biophysical protein methods to measure protein stability and properties
  • Thorough understanding of protein folding, enzymatic function, and rational design protein engineering
  • Ability to independently drive scientific progress and deliver on corporate goals and timelines
  • Lead root-cause identification of enzyme performance and implement mitigations.
  • Desired experience in the following technical areas:
  • Biophysical protein characterization of polymerases
  • Next-generation sequencing
  • Kinetics and enzymology
  • Reagent development

  • Leadership and management skills:
  • Success in this position requires frequent communication with peers and management. These relationships must be built on respect, integrity, cooperation, teamwork and professionalism
  • Excellent problem solving and project management skills
  We are passionate about our mission to develop high performing products to study genomics in an unprecedented flexibility and to understand biology for the improvement of healthcare. We have built a highly efficient product-driven organization where employees can learn, grow and thrive in a challenging but encouraging environment.  We are committed to scientific integrity, collegiality, honesty, objectivity, and openness.   We offer excellent benefits, which include a 401K plan, competitive health benefits, flexible vacation, and equity incentives.  We foster an environment such that all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation, gender identity or expression, age, disability, veteran status or any other characteristics protected by law.