Senior Scientist, Purification

Sunnyvale Protein Production
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We are passionate about our mission to develop high performing products to study genomics with unprecedented flexibility and to understand biology for the improvement of healthcare. We have built a highly efficient product-driven organization where employees can learn, grow and thrive in a challenging but encouraging environment.  We are committed to scientific integrity, collegiality, honesty, objectivity, and openness.   We offer excellent benefits, which include a 401K plan, competitive health benefits, flexible vacation, and equity incentives.


  • Lead projects in the enzyme area to support the transfer and commercialization of the product/process, including design and implementation of processes, QC’s, and purification methods to build out a robust manufacturing line.
  • Design, plan, and execute product and process characterization experiments and stability studies.
  • Lead the design of experiments, driving execution, data analysis, and presentation of outcomes, making recommendations based on data.
  • Execute experiments to develop and optimize bacterial protein purification for R&D product.
  • Scale up from mg to grams for manufacturing purification process development, validation, and production
  • Build manufacturing documentation for user and system requirements.
  • Lead complex investigations, troubleshooting product performance issues.
  • Other duties as assigned.


  • Experience in pilot/full-production environments, including tech transfer activities, sustaining support, and continuous improvement is required.
  • Hands on experience with AKTA instrumentation is required.
  • Strong working experience with various research-scale affinity methods and Mfg. grams’ scale for protein purification and production.
  • Independently designing and executing protocols.
  • Familiarity with various modes of chromatography (IEX, HIC, RPC, SEC, affinity) is a must.
  • Experience in protein characterization (HPLC SEC/RP, qPCR, Kinetic Assay and SeqStudio Genetic Analyzer system) is preferred.
  • Experience with manufacturing infrastructure setup such as WI, SOP, BOM and MBR.
  • Creative and independent thinker; excellent communication skills; good team worker; ability to multitask and work independently; and ability to find creative solutions to problems are required.

Other Qualifications:

  • Strong organizational skills and attention to detail.
  • Able to work effectively in a fast-paced, start-up company environment.
  • Strategic agility, strong critical and logical thinking with ability to analyze problems.
  • Strong ability to prioritize, multi-task, and work in an evolving environment.
  • Self-motivated individual with good record keeping and good written and verbal communication skills.
  • Prepare and present project updates to ensure timely delivery.


  • BS/MS/PhD. in Molecular biology, Biochemistry and Protein chemistry or a related discipline (an equivalent combination of experience and education may be considered).
  • At least 5 years' academic or industry experience developing, validating, and implementing recombinant protein production workflows.

Relevant experience in the life science industry is preferred